Multiple lines of evidence now indicate

2019-08-28

Multiple lines of evidence now indicate that mitochondrial decay is a fundamental factor that leads to alterations in energy metabolism in the aged heart (Hagen et al., 2002, Judge and Leeuwenburgh, 2007, Lesnefsky et al., 2001c).

Dysfunction of the ubiquitin proteasome system

2019-08-27

Dysfunction of the ubiquitin-proteasome system causes abnormal organelle morphology and impairs sperm formation and maturation steps resulting in male infertility

As the communications interface was developed by two separat

2019-08-26

As the communications interface was developed by two separate organisations with differing software processes and tools, a modular approach to the safety case was deemed appropriate.

CellProfiler and OpenComet are two open source software avai

2019-08-24

CellProfiler and OpenComet are two open source software available in internet to analyse silver stained comet assay images.

It is of interest that an

2019-08-23

It is of interest that an initial maternal experience in virgin mice produces both changes in subsequent maternal behavior as well as possible changes in neural gene expression. Stolzenberg et al.

Advances in the total chemical synthesis of

2019-08-22

Advances in the total chemical synthesis of ubiquitin have enabled the efficient synthesis of new and improved ubiquitin-based reagents. Using an optimized linear synthesis, ubiquitin can now be easily obtained in high yield and purity [35].

br Acknowledgements This work was supported by

2019-08-21

Acknowledgements This work was supported by National Natural Science Foundation of China (No. 81400241).

Finally we have determined for

2019-08-20

Finally, we have determined for the first time that aromatase enzyme activity is necessary to observe IGF-1-dependent Rotenone receptor activation.

br Results br Discussion Our UbV library was originally desi

2019-08-19

Discussion Our UbV library was originally designed to develop inhibitors of deubiquitinases (Ernst et al., 2013).

br Regulation of cadherin switching The

2019-08-17

Regulation of cadherin switching The downregulation of E-cadherin during cadherin switching is induced by multiple mechanisms, including methylation of the E-cadherin promoter and signaling pathways that activate E-cadherin-suppressing transcription factors [[61], [62], [63]].

Despite its significance in tumor suppression the molecular

2019-08-16

Despite its significance in tumor suppression, the molecular mechanism by which DAPK is regulated and its interplay with other tumor suppressors and oncoproteins have not been completely unraveled.

How does APC C recognize its substrates and catalyze their

2019-08-15

How does APC/C recognize its substrates and catalyze their ubiquitylation?

DDI is one of the main problems with serious

2019-08-14

DDI is one of the main problems with serious clinical consequences in clinical settings.

br E E backside interaction The E possesses an

2019-08-13

E3–E2 backside interaction The E2 possesses an important regulatory interface which is termed its backside as it is opposite to the catalytic cleft that bears the active-site cysteine forming the thioester with SUMOD.

Hello world!

2018-07-29