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Then we explored the MCLEIA methodology parameters including
2019-09-16

Then, we explored the MCLEIA methodology parameters including precision, accuracy and specificity. In the 0.5–128 ng/mL, the standard curve equation was = 0.5014 + 1.769 ( was log, was RLU/RLU with a correlation coefficient of 0.9907) (). On the one hand, same sample (0.5, 4.0, 32.0 ng/mL) detecte
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As for antiviral activity eight
2019-09-16

As for antiviral activity, eight out of 23 synthesized compounds were active against influenza B virus with EC50 values in the range of 0.19–39 μM. Four of the eight influenza B hits were active against influenza A and two were also active against RSV (4 and 6, EC50 = 0.40 and 1.8 μM, respectively).
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For example nM MTX markedly stimulates
2019-09-16

For example, 200nM MTX markedly stimulates the differentiation of the monocytic U937 Tubacin [39], but only 10nM MTX is sufficient for the inhibition of clonogenicity in the ALL and APL cell lines [22]. Furthermore, an even lower concentration of MTX (2nM) selectively induces the expression of p27
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As for the molecular mechanism Ferguson BD suggested that
2019-09-12
As for the molecular mechanism, Ferguson BD suggested that EphB4/EphrinB2 stimulation induced topoisomerase I activity in small cell lung cancer cell lines.
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Introduction Angiotensin II Ang II and Endothelin ET are
2019-09-11
Introduction Angiotensin II (Ang II) and Endothelin 1 (ET-1) are potent vasoconstrictive peptides recognized as key players in many cardiovascular diseases [1].
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Gap 26 In order to further understand the
2019-09-10
In order to further understand the biological significance of cell-collagen X interactions, we have examined the possibilities of involvement of other collagen receptors in cell binding to collagen X.
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br User knowledge representation Various representation appr
2019-09-09
User knowledge representation Various representation approaches of user interests and preferences are proposed.
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A second advance came with the
2019-09-07
A second advance came with the discovery that conformationally-flexible benzamide analogs having an N-phenylpiperazine moiety possessed good affinity and modest selectivity for D3 versus D2 receptors [3,[14], [15], [16]].
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br The LSCP model and its
2019-09-06
The LSCP model and its properties In this section, we first introduce the LSCP model in Section 2.1.
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Collectively the results presented here provide
2019-09-05
Collectively, the results presented here provide new insights into ligand binding, clustering, spatial distribution, and phosphorylation of DDR1b and DDR2 in response to soluble collagen I.
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In rodents but not humans two splice variants of
2019-09-04
In rodents but not humans, two splice variants of Chk are identified as Ntk and Ctk, which possess and lack the N-terminal unique domain, respectively.
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In agreement with the evidence on the Plg binding function
2019-09-03
In agreement with the evidence on the Plg-binding function of tapeworm enolases, eukaryotic enolases have been shown to be multifunctional proteins, with other activities besides their role as glycolytic enzymes (Pancholi, 2001).
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Se-Aspirin This review focuses on the atomic basis
2019-09-02
This review focuses on the atomic basis of CRM1-mediated nuclear export.
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Several mechanisms are implicated in lipid induced insulin r
2019-08-30
Several mechanisms are implicated in lipid-induced insulin resistance in muscle, including oxidative stress (Koves et al., 2008, Zhang et al., 2011, Muoio and Neufer, 2012).
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Tivantinib br A brief history of RBR E
2019-08-29
A brief history of RBR E3s RBR E3s were originally defined based on sequence alignments that predicted a tripartite motif of three zinc (Zn)-binding domains
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