• For example nM MTX markedly stimulates

  2019-09-16

  

  For example, 200nM MTX markedly stimulates the differentiation of the monocytic U937 Tubacin [39], but only 10nM MTX is sufficient for the inhibition of clonogenicity in the ALL and APL cell lines [22]. Furthermore, an even lower concentration of MTX (2nM) selectively induces the expression of p27

• As for the molecular mechanism Ferguson BD suggested that

  2019-09-12

  As for the molecular mechanism, Ferguson BD suggested that EphB4/EphrinB2 stimulation induced topoisomerase I activity in small cell lung cancer cell lines.

• Introduction Angiotensin II Ang II and Endothelin ET are

  2019-09-11

  Introduction Angiotensin II (Ang II) and Endothelin 1 (ET-1) are potent vasoconstrictive peptides recognized as key players in many cardiovascular diseases [1].

• Gap 26 In order to further understand the

  2019-09-10

  In order to further understand the biological significance of cell-collagen X interactions, we have examined the possibilities of involvement of other collagen receptors in cell binding to collagen X.

• br User knowledge representation Various representation appr

  2019-09-09

  User knowledge representation Various representation approaches of user interests and preferences are proposed.

• A second advance came with the

  2019-09-07

  A second advance came with the discovery that conformationally-flexible benzamide analogs having an N-phenylpiperazine moiety possessed good affinity and modest selectivity for D3 versus D2 receptors [3,[14], [15], [16]].

• br The LSCP model and its

  2019-09-06

  The LSCP model and its properties In this section, we first introduce the LSCP model in Section 2.1.

• Collectively the results presented here provide

  2019-09-05

  Collectively, the results presented here provide new insights into ligand binding, clustering, spatial distribution, and phosphorylation of DDR1b and DDR2 in response to soluble collagen I.

• In rodents but not humans two splice variants of

  2019-09-04

  In rodents but not humans, two splice variants of Chk are identified as Ntk and Ctk, which possess and lack the N-terminal unique domain, respectively.

• In agreement with the evidence on the Plg binding function

  2019-09-03

  In agreement with the evidence on the Plg-binding function of tapeworm enolases, eukaryotic enolases have been shown to be multifunctional proteins, with other activities besides their role as glycolytic enzymes (Pancholi, 2001).

• Se-Aspirin This review focuses on the atomic basis

  2019-09-02

  This review focuses on the atomic basis of CRM1-mediated nuclear export.

• Several mechanisms are implicated in lipid induced insulin r

  2019-08-30

  Several mechanisms are implicated in lipid-induced insulin resistance in muscle, including oxidative stress (Koves et al., 2008, Zhang et al., 2011, Muoio and Neufer, 2012).

• Tivantinib br A brief history of RBR E

  2019-08-29

  A brief history of RBR E3s RBR E3s were originally defined based on sequence alignments that predicted a tripartite motif of three zinc (Zn)-binding domains

• Multiple lines of evidence now indicate

  2019-08-28

  Multiple lines of evidence now indicate that mitochondrial decay is a fundamental factor that leads to alterations in energy metabolism in the aged heart (Hagen et al., 2002, Judge and Leeuwenburgh, 2007, Lesnefsky et al., 2001c).

• Dysfunction of the ubiquitin proteasome system

  2019-08-27

  Dysfunction of the ubiquitin-proteasome system causes abnormal organelle morphology and impairs sperm formation and maturation steps resulting in male infertility

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