• Several mechanisms are implicated in lipid induced insulin r

  2019-08-30

  Several mechanisms are implicated in lipid-induced insulin resistance in muscle, including oxidative stress (Koves et al., 2008, Zhang et al., 2011, Muoio and Neufer, 2012).

• Tivantinib br A brief history of RBR E

  2019-08-29

  A brief history of RBR E3s RBR E3s were originally defined based on sequence alignments that predicted a tripartite motif of three zinc (Zn)-binding domains

• Multiple lines of evidence now indicate

  2019-08-28

  Multiple lines of evidence now indicate that mitochondrial decay is a fundamental factor that leads to alterations in energy metabolism in the aged heart (Hagen et al., 2002, Judge and Leeuwenburgh, 2007, Lesnefsky et al., 2001c).

• Dysfunction of the ubiquitin proteasome system

  2019-08-27

  Dysfunction of the ubiquitin-proteasome system causes abnormal organelle morphology and impairs sperm formation and maturation steps resulting in male infertility

• As the communications interface was developed by two separat

  2019-08-26

  As the communications interface was developed by two separate organisations with differing software processes and tools, a modular approach to the safety case was deemed appropriate.

• CellProfiler and OpenComet are two open source software avai

  2019-08-24

  CellProfiler and OpenComet are two open source software available in internet to analyse silver stained comet assay images.

• It is of interest that an

  2019-08-23

  It is of interest that an initial maternal experience in virgin mice produces both changes in subsequent maternal behavior as well as possible changes in neural gene expression. Stolzenberg et al.

• Advances in the total chemical synthesis of

  2019-08-22

  Advances in the total chemical synthesis of ubiquitin have enabled the efficient synthesis of new and improved ubiquitin-based reagents. Using an optimized linear synthesis, ubiquitin can now be easily obtained in high yield and purity [35].

• br Acknowledgements This work was supported by

  2019-08-21

  Acknowledgements This work was supported by National Natural Science Foundation of China (No. 81400241).

• Finally we have determined for

  2019-08-20

  Finally, we have determined for the first time that aromatase enzyme activity is necessary to observe IGF-1-dependent Rotenone receptor activation.

• br Results br Discussion Our UbV library was originally desi

  2019-08-19

  Discussion Our UbV library was originally designed to develop inhibitors of deubiquitinases (Ernst et al., 2013).

• br Regulation of cadherin switching The

  2019-08-17

  Regulation of cadherin switching The downregulation of E-cadherin during cadherin switching is induced by multiple mechanisms, including methylation of the E-cadherin promoter and signaling pathways that activate E-cadherin-suppressing transcription factors [[61], [62], [63]].

• Despite its significance in tumor suppression the molecular

  2019-08-16

  Despite its significance in tumor suppression, the molecular mechanism by which DAPK is regulated and its interplay with other tumor suppressors and oncoproteins have not been completely unraveled.

• How does APC C recognize its substrates and catalyze their

  2019-08-15

  How does APC/C recognize its substrates and catalyze their ubiquitylation?

• DDI is one of the main problems with serious

  2019-08-14

  DDI is one of the main problems with serious clinical consequences in clinical settings.

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