• br Acknowledgements This work was

  2021-01-06

  

  Acknowledgements This work was supported in part by JSPS KAKENHI Grant Number 26292031. Introduction The Cys-loop receptors constitute an important superfamily of ligand-gated ion TP-0903 (LGICs) and mediate synaptic transmission in both invertebrate and vertebrate nervous systems (Jones et a

• Previous research has suggested that the acetylcholine gated

  2021-01-06

  

  Previous research has suggested that the acetylcholine-gated chloride channels (ACCs) in Caenorhabditis elegans (Putrenko et al., 2005) exhibit the characteristics of promising drug targets. The genes that encode the various subunits of this family are present across the nematode phylum and appear t

• Kshirsagar et al previously reported an association between

  2021-01-06

  

  Kshirsagar et al. previously reported an association between CHK2thr68 expression and the presence of the chromatin remodeling factor Rsf-1 in solid HGSC specimens [22]. Rsf-1 expression was previously analyzed in our effusion series and was found to be related to poor survival [23]. Analysis of the

• Also important in binding of E to the ER is

  2021-01-06

  

  Also important in binding of E2 to the ER is the hydroxyl on the D ring, which has a stabilizing contact with His-524 in ERα (Fig. 7) and with His-475 in ERβ (Fig. S1) [8,9,36,37]. The spatial relationship of the functional groups on the A and D rings on E2 has been used to develop chemicals contai

• ERR is expressed in several

  2021-01-06

  

  ERRγ is expressed in several adult and embryonic tissues but its biological role is still largely unknown [21]. Overexpression of ERRγ in breast cancer correlates with a favorable outcome [22]. In addition, ERRγ has been reported to inhibit the growth of prostate tumor PTC209 HBr [23]. In this stud

• br Materials and methods br Results Artemis has been

  2021-01-06

  

  Materials and methods Results Artemis has been reported to possess 5′–3′ exonuclease activity in vitro on ssDNA, as well as DNA-PK-dependent endonuclease activity on single-strand overhang and hairpin DNA structures [11]. However, enzymes within the metallo-β-lactamase family typically contain

• br Materials and methods br Results br Discussion The presen

  2021-01-06

  

  Materials and methods Results Discussion The present work demonstrates the functional role of DGAT2 in elevating the neutral lipid accumulation in engineered N. oceanica, which have aroused a great deal of interest in industrial scale biofuel production. Recently, there have been increasing

• br Results and Discussion br Materials and Methods

  2021-01-06

  

  Results and Discussion Materials and Methods Acknowledgements Introduction Among the solid tumors, Prostate cancer (PCa) has been one of the most frequently diagnosed malignancy in men and the second male's cancer related deaths in the developed countries [1]. In China, the incidence and

• Adenosine 5-monophosphate mg Many filarial species harbor an

  2021-01-06

  

  Many filarial species harbor an endosymbiotic bacterium of the genus Wolbachia. A recent investigation of Wolbachia distribution in 35 filarial species including 28 species and 7 genera and/or subgenera have shown that 37% of them harbor Wolbachia (Ferri et al., 2011). In filarial nematodes, Wolbach

• br Introduction The allergic response is a complex

  2021-01-06

  

  Introduction The allergic response is a complex process involving the interaction of several mediators; among these, cysteinyl leukotrienes (CysLTs) represent one of the most important actors in the pathogenesis of airway allergic diseases such as allergic rhinitis and asthma [1]. Pharmacological

• It was recently reported that a functional

  2021-01-05

  

  It was recently reported that a functional single nucleotide polymorphism (rs75932628) within Triggering receptor expressed on myeloid nibr 2 (TREM2) is associated with AD (Guerreiro et al., 2013). Homozygous loss of function mutations in TREM2 are also associated with an autosomal recessive form o

• Materials and methods br Results br Discussion Hydroxylation

  2021-01-05

  

  Materials and methods Results Discussion Hydroxylation of proline in bacterial Ginsenoside Rb1 australia is one of the oxygen-requiring metabolic reactions, which needs efficient oxygen. Oxygen supply is always a rate-limiting step for tyrosinase production even though pure oxygen is purged i

• jak stat pathway Long stretches of ssDNA have also been obse

  2021-01-05

  

  Long stretches of ssDNA have also been observed in rad53-1 mutant jak stat pathway under replication stress using EM images (Sogo et al., 2002). Deletion of EXO1, a 5′-to-3′ exonuclease, can suppress the generation of ssDNA detected in rad53-1 mutant cells (Cotta-Ramusino et al., 2005). It was thus

• As a functional ETC is required for DHODH catalysis

  2021-01-05

  

  As a functional ETC is required for DHODH catalysis (Loffler, Jockel, Schuster, & Becker, 1997; Rawls, Knecht, Diekert, Lill, & Loffler, 2000; Zameitat, Freymark, Dietz, Loffler, & Bolker, 2007), DHODH depends on the mitochondrial ETC to generate adequate concentrations of ubiquinone (Fig. 2). Cells

• Introduction Psoralea corylifolia L Leguminosae is a well kn

  2021-01-05

  

  Introduction Psoralea corylifolia L. (Leguminosae) is a well-known traditional Chinese medicine, and it has been widely used for the treatment of various diseases like bronchial asthma, leucopenia, vitiligo and psoriasis in East Asian countries (Zhang et al., 1990). Previous studies have reported

12640 records 598/843 page Previous Next First page 上5页 596597598599600 下5页 Last page