• ATP dependent DNA ligases in

  2021-02-26

  

  ATP-dependent DNA ligases in vertebrates are divided in three families [7]. Family I DNA ligases are responsible for sealing the nicks during DNA replication and in long-patch base excision repair (BER). Family III DNA ligases are involved in short-patch BER. Lastly, family IV DNA ligases are involv

• Considering the divergence of multiple DGAT isoforms we exam

  2021-02-26

  

  Considering the divergence of multiple DGAT isoforms, we examined whether MiDGAT1 and MiDGAT2s utilized different fatty acids as the substrate to synthesize TAGs. GC-MS analysis indicated that C16:0 and C18:0 were the major components of TAGs in yeast cells, and all three MiDGATs displayed the same

• br DDR in atherosclerosis and vascular disease The

  2021-02-26

  

  DDR1 in atherosclerosis and vascular disease The Canadian group of Bendeck, explored the role of DDR1 in repair following arterial injury in rats [30]. DDR1 protein levels, assessed via Western blots prepared from arterial extracts taken at various times after injury, showed DDR1 protein dramatic

• CYP enzymes have an important role in

  2021-02-26

  

  CYP450 8220 have an important role in microsomal oxidase function across a broad range of taxa (Pakharukova et al., 2012). They are involved in metabolism and detoxification of both internally generated compounds and xenobiotics as the phase I metabolizing enzymes and play an important role in main

• In patients with CTEPH ET levels

  2021-02-26

  

  In patients with CTEPH, ET-1 levels are raised and have been shown to fall after PEA surgery [24]. After an acute pulmonary embolism there is obstruction of the pulmonary trk inhibitor by acute thrombus and elevated levels of ET-1 [28], [30]. Elevated levels of ET-1 have also been observed in air em

• br Acknowledgments br Introduction Ubiquitin ligases limit

  2021-02-26

  

  Acknowledgments Introduction Ubiquitin ligases limit the stability and activity of substrates by targeting them for proteasomal-dependent degradation. Siah is a two-member family of ubiquitin ligases implicated in control of key cellular processes. Among those, Siah ligases control prolyl hydr

• br Introduction Melatonin mainly originates

  2021-02-26

  

  Introduction Melatonin mainly originates from the pineal gland (Reiter, 1991) and is well known for its physiological functions in the regulation of circadian rhythms (Cajochen et al., 2003) and as a potent free radical scavenger and broad-spectrum antioxidant in mammals (Paradies et al., 2010, T

• br Conclusion br Conflict of

  2021-02-25

  

  Conclusion Conflict of interest Introduction The sexual exploitation and internal trafficking of British children within the UK has received growing public and policy attention in recent years. This has largely been in response to a number of high profile police investigations into cases in

• Of note BRQ and LFM are two well known immunosuppressive

  2021-02-25

  

  Of note, BRQ and LFM are two well-known immunosuppressive agents (Batt, 1999). As for LFM, it was reported as immunosuppressive therapy for bone marrow (Avery et al., 2004) and renal (Chon and Josephson, 2011) transplantation. Accumulating evidence indicated that organ transplant patients irrelevant

• The authors gratefully acknowledge financial support from th

  2021-02-25

  

  The authors gratefully acknowledge financial support from the State of São Paulo Research Foundation (FAPESP, Fundação de Amparo à Pesquisa do Estado de São Paulo), grants 2013/07600-3 and 2013/25658-9, and the National Council for Scientific and Technological Development (CNPq, Conselho Nacional de

• The CYP A genes are regulated physiologically by glucocortic

  2021-02-25

  

  The CYP3A genes are regulated physiologically by glucocorticosteroids, growth hormone, thyroid hormones and cytokines [13, 20, 30]. It has been shown that glucocorticoid receptor (GR), pregnane X receptor (PXR), constitutive androstane receptor (CAR) and vitamin D receptor (VDR) play an important ro

• Increasing age among middle aged subjects years old

  2021-02-25

  

  Increasing age among middle-aged subjects (30–59years old) was associated with higher levels of cholesterol synthesis markers (although without statistical significance) and also of cholesterol Hydrochlorothiazide markers (with statistical significance for campesterol and sitosterol); this finding

• Dose response analysis Fig can be performed on

  2021-02-25

  

  Dose response analysis (Fig. 2) can be performed on Ropivacaine HCl synthesis in culture, in tissue, in animals or even in patients. Many different responses can be measured, including mRNA levels, reporter gene activity, gene product (e.g. enzyme) activity or even physiological functions such as in

• The mechanism by which OC use leads

  2021-02-25

  

  The mechanism by which OC use leads to impaired glucose tolerance is yet to be fully clarified. Decreased insulin sensitivity appears to be mainly accounted for by estrogenic component and this effect may be modified by progestogenic component [14], [15]. Estrogenic effect on glucose tolerance has b

• br STAR Methods br Author Contributions br Acknowledgments T

  2021-02-25

  

  STAR★Methods Author Contributions Acknowledgments The authors thank Monika Kuhn for excellent technical assistance and Dr. Antje Schäfer for valuable scientific input. H.S. was supported by the DFG (FZ 82; Graduate School of Life Sciences and SCHI 425-6/1), and A.V.S. by Northwestern Univer

12640 records 572/843 page Previous Next First page 上5页 571572573574575 下5页 Last page