• These observations are of particular interest

  2022-06-17

  

  These observations are of particular interest in the context of recent conceptual changes regarding the mechanisms by which different types of leukocytes contribute to atherogenesis. Over the last decade, the paradigm of the predominant circulatory origin of lesional macrophages has been challenged

• br Acknowledgments R Dalmann has obtained a

  2022-06-17

  

  Acknowledgments R. Dalmann has obtained a “bourse Cifre” (grant 304/2011) from the ‘Association Nationale de la Recherche Technique’ and Bristol-Myers-Squibb. Introduction Endocannabinoids, their molecular targets (receptors), their synthetic and degrading enzymes and proteins that transport

• br Epigenetic regulation of OA pathogenesis Although epigeno

  2022-06-16

  

  Epigenetic regulation of OA pathogenesis Although epigenome of each cell is unique but can undergo temporal and spatial changes in response to environmental stimuli such as diet, exercise, smoking and disease status. Aberrant epigenetic modifications due to environmental factors are associated wi

• blt2 Work is presently underway to

  2022-06-16

  

  Work is presently underway to unveil mechanisms whereby SAHA-dependent restoration of cardiomyocyte autophagic flux is protective. Another interesting question pertains to mechanisms whereby class I and class II HDAC inhibitors induce autophagy. It has been demonstrated that TSA reduces transverse a

• br Conclusion The addition of cellulose to

  2022-06-16

  

  Conclusion The addition of Bufexamac to natural substrate increases the number of H-bonds which indicates an increase in the stability of the docking systems. The investigated compounds are more stable than natural substrate in docking systems, where the natural substrate has two H-bonds while t

• Adenine In summary we propose a

  2022-06-16

  

  In summary, we propose a model that explains the possible mechanism the HULC mediates activation of HBV in liver cancer Adenine (Fig. 8). In the model, HULC promotes the expression of miR-539 by stimulating HBx-co-activated STAT3. Then, miR-539 down-regulates APOBEC3B, leading to an increase of HBV

• A more quantitative view of kinase

  2022-06-16

  

  A more quantitative view of kinase specificity suggests a continuum of phosphorylation rates for the various substrates of a particular kinase (Figure 4A). Such differences in ‘substrate quality’ can arise from variations in phosphorylation site or docking sequences and may explain why the timing or

• Previous reports have implicated the guanylin GC C

  2022-06-16

  

  Previous reports have implicated the guanylin/GC-C signalling system as being important in osmoregulation in fish, especially in euryhaline species such as the eel which migrate between freshwater (FW) and seawater (SW) environments at different stages of their life cycle (Comrie et al., 2001a, Comr

• The absence of direct oxidation of Fe by L

  2022-06-16

  

  The absence of direct oxidation of Fe2+ by L1 in experiments in solution would be consistent with the recognized low O2 affinity of sGC. It is known that, in buy flumazenil with other hemoproteins, such as globins and heme-containing oxygenases with a Fe2+-proximal histidine linkage, sGC prevents o

• Two different genes encode GSK isoforms and that

  2022-06-16

  

  Two different genes encode GSK-3 isoforms α and β that have very similar catalytic domains but significantly differ in their N- and C-termini. The α and β isoforms split from a common precursor approximately at the emergence of vertebrates, suggesting that at least one of the isoforms took on a new

• br Introduction Few decades after of HIV AIDS diagnosis

  2022-06-16

  

  Introduction Few decades after of HIV/AIDS diagnosis, it has been still a health problem and impact will continue in the next decades. In 2015, HIV/AIDS was the 12th cause of death in the world and it's estimated that 1.2 million people was died of HIV/AIDS this year. In the global epidemiologica

• We tested this hypothesis with two

  2022-06-16

  

  We tested this hypothesis with two experiments. In the first experiment OVX monkeys implanted with an E2 crf1 (this results in LH levels similar to the level during the follicular phase) were treated with daily injections of letrozole for 1 week and then EB was injected systemically mimicking the p

• Through the analysis of various synthetic GPR agonists as

  2022-06-16

  

  Through the analysis of various synthetic GPR40 agonists as reported in literature, we found that a number of these compounds contained a phenylpropanoic SR 1664 motif which was inspired from naturally occurring medium to long chain fatty acids. For instance, in the early period of discovering TAK-

• EAATs can transport glutamate aspartate cysteic acid and ser

  2022-06-16

  

  EAATs can transport glutamate, aspartate, cysteic acid, and serine-o-sulfate (Bjorn-Yoshimoto and Underhill, 2016). All EAATs work as symporters co-transporting 2 or 3 molecules of Na+ and a proton with each molecule of glutamate (or aspartate). In addition, a K+ ion is counter-transported ending in

• With the advent of genome sequencing hexokinase gene sequenc

  2022-06-16

  

  With the advent of genome sequencing, hexokinase gene sequences are now available from a far greater number of vertebrate species, as well as from diverse non-vertebrate animal species. As indicated above, searches of vertebrate genome sequences revealed the existence of a novel fifth member of the

12644 records 413/843 page Previous Next First page 上5页 411412413414415 下5页 Last page