• Apoptosis via Fas FasL system has been evidenced to

  2022-08-25

  

  Apoptosis via Fas/FasL system has been evidenced to play a role in the pathogenesis of many diseases [26], [27], [28], [29], [30], [31], [32], [33], [34]. Along with these, Fas/FasL system has an important role in progressive renal disease and organ rejection in renal, cardiac and liver transplanta

• The effect of combined A and

  2022-08-24

  

  The effect of combined A-192621 and PD 155080 treatment on the Epinephrine Bitartrate mg during endotoxin infusion is quite different compared to either drug used alone (Wanecek et al., 1999). After administration of both antagonists in combination, cardiac index increased to baseline values within

• fxr agonist br Conclusion The mitochondrial and glycolytic e

  2022-08-24

  

  Conclusion The mitochondrial and glycolytic energy metabolism of the brain is coordinated by HKI binding to MOM, although the molecular mechanism of such a regulation is not yet clear. The fxr agonist for HKI in MOM are VDACs [[5], [6], [7]], mainly the VDAC1 isoform [8]. Using a computational m

• It is noticeable that CO as well as H pylori

  2022-08-24

  

  It is noticeable that CO as well as H. pylori suppresses apoptosis while it induces autophagy in AGS cells. The differential effects of CO on the activation of transcription factors responsible for regulating expression of apoptosis- and autophagy-related genes merit further investigation. In concl

• Several layers of regulation for this

  2022-08-24

  

  Several layers of regulation for this canonical activation of the HH pathway exist. First, the protein kinase A (PKA), the casein kinase 1α (CK1α) and GSK3β can phosphorylate and mark for proteosomal degradation the GLI transcription factors. [36] Second, Suppressor of Fused (SUFU) binds to GLI and

• It is difficult however to assure that observed alterations

  2022-08-24

  

  It is difficult, however, to assure that observed alterations of pro-oxidant/antioxidant levels within the studied organisms are related directly to heavy metal pollution, rather than to other accompanying environmental stressors. Environmental factors like oxygen partial pressure, temperature, sali

• br Membrane Fusion Requires Rab GTPases Tethers and

  2022-08-24

  

  Membrane Fusion Requires Rab-GTPases, Tethers, and SNAREs Regulation and Function of Rab5 Following endocytosis in metazoan cells, the Rab5-specific GEF Rabex5 binds to ubiquitinated cargo proteins, such as cell surface receptors or metabolite transporters, and subsequently activates Rab5 on e

• G protein coupled receptors GPCRs constitute a large family

  2022-08-24

  

  G-protein coupled receptors (GPCRs) constitute a large family of 7 trans-membrane-spanning proteins that activate internal signal transduction cascades through binding to different ligands including neurotransmitters, peptides, and lipids [7]. This family of receptors has therapeutic potentials in t

• PBI is an agonist of

  2022-08-24

  

  PBI-4050 is an agonist of GPR40 and acts as an antagonist or inverse agonist of GPR84. It cannot be excluded that other targets besides GPR40 and GPR84 could be implicated in the mechanism of action of PBI-4050 and could be explored in future studies. However, the present study, and in particular th

• Finally a potentially effective therapeutic approach is to

  2022-08-24

  

  Finally, a potentially effective therapeutic approach is to target the LDH enzymes that mediate bidirectional conversion of pyruvate into lactate. In particular, because LDHA is the predominant isoform expressed in glycolytic tumours, an array of LDHA-targeting compounds have been proposed and valid

• Some biguanides can cross the

  2022-08-24

  

  Some biguanides can cross the mitochondrial membrane and increase L-lactate formation by inhibiting oxidative cannabinoid receptors [34]. On the other hand, it has also been reported that levels of fasting plasma lactate in T2DM patients are similar regardless of whether or not metformin is adminis

• TGR is a class A

  2022-08-24

  

  TGR5 is a class A GPCR, transducing signal through Gs-protein mediated cAMP accumulation, and was recently reclassified as the founder member of the bile–acid receptor subclass of GPCRs [22]. The cAMP-mediated signaling of TGR5 activation has been implicated in a range of cellular physiological acti

• br Materials and methods br

  2022-08-24

  

  Materials and methods Results Discussion Conclusion Pharmacophore modeling was applied to explore new probable Glo-I inhibitors. Ninety two pharmacophoric models were generated representing diverse types of interaction between co-crystallized ligands and corresponding binding site. The g

• Ning et al showed that LPC appeared to increase

  2022-08-24

  

  Ning et al. showed that LPC 18:1 appeared to increase insulin release through both GPR119-dependent and -independent mechanisms (Ning et al., 2008). In our study, we have shown that not only GPR119 but also GPR40 and GPR55 participate in LPC-stimulated insulin secretion (Fig. 4, Fig. 5) and target p

• Rivaroxaban mg In addition this study also showed no obvious

  2022-08-24

  

  In addition, this study also showed no obvious increase in apoptosis but obvious increase in necrosis after WZB117 treatment. The possible reason is that apoptosis is an ATP-utilizing process which is an active and programmed form of cell death. In contrast, necrosis is an uncontrolled or pathologic

12644 records 377/843 page Previous Next First page 上5页 376377378379380 下5页 Last page